Tóm tắt

Osteoporosis in patients had Cushing’s syndrome by long-term using glucocorticoids is dual risk factors of fractures, disability and death. The metabolic disordersin Cushing’s syndrome by long-term using of glucocorticoids created a complex clinical feature and a bad outcome for osteoporosis. Objects: 1. Describe the clinical, paraclinical feature relatively of osteoporosis in 64 patients with Cushing’s syndrome long-term use of glucocorticoids at the endocrinology department, Hai Duong General Hospital. 2. Determine the rate of osteoporosis by dual energy X-ray absorptiometry and relative factors. Methods: Cross-sectional study, 64 patients with Cushing’s syndrome by long-term use of glucocorticoids at the endocrinology department, Hai Duong General Hospital from March to September, 2018. All patients are calculated BMD by DEXA at lumber spine, X ray vertebral column and tested some relative factors of osteoporosis. Results and Conclusions: 64 in-patients were included, containing 17 (26.6%) males and 47 (73.4%) females; mean age were 64,7 ± 12.6 years old; 50 year and more 89%. Ache of bone 100%; vertebral flat 65,6%; vertebral hump backed 40,0%; fracture 32,8%; and others problems: hypertension 78,1%; overweight and obesity 43,8%; abnormal fat 92,2%, abnormal WHR 93,8%; low cortisol concentrate 67,2%; high cortisol concentrate 6,2%; normal ACTH 78,1%; low ACTH 15,2%; osteoporosis in Cushing’s syndrome by using glucocorticoids for a longtime 62,5%; low BMD 32,3%; vertebral X - ray: 12,5% none hurt; above sunken of vertebra 28,1%; amphicoelous centra 25,0%; wedge vertebra 18,8%; blade vertebra 15,6%; more 60 years old, osteoporosis 65%, females with osteoporosis higher than males; osteoporosis with abnormal fat 95%; abnormal WHR 92,5%; lipid disorders 87,5%; low cortisol 67,5%.