Tóm tắt
Stroke is the third most common cause of disability and also the second leading cause of death worldwide. A lot of studies have confirmed that markedly elevated serum level of S100B protein and NSE is associated with poor outcomes, but the cut-off value is varied. Objective: Assessing the level of S100B protein and NSE and its role in early diagnosis and prognosis of acute ischemic stroke. Method: Descriptive, cross sectional study, compare with control group and follow up. Subject: case group include 96 patients with acute ischemic stroke in Hue Central Hospital, control group include 105 healthy persons similar in age, sex, race and region to case group. Results: Median level of S100B protein and NSE in case group are 0.404 ng/ml and 26.55 ng/ml, in control group are 0.058 ng/ml and 14.47 ng/ml, respectively. Cut-off value of S100B protein >0.119 ng/ml, NSE> 22.3 ng/ml, have sensitivity of 83.3% and 61.5%, specificity of 98.1% and 98.1%, respectively.