Abstract
Objective: The syndrome of thyroid hormone resistance is characterized by a reduced responsiveness of target tissues to thyroid hormone due to mutations on the thyroid hormone receptor. Method: We report two cases of thyroid hormone resistance syndrome with the level of TSH that is not correlated with FT4 level. Results: The first case: Mutation c.938T>C (p.Met313Thr) located at THRB exon 10. The second case: Mutation c.1348C > G (L450V) located at THRB exon 11. Conclusion: When approaching a patient with non - specific hyperthyroid state and non - significant correlation between TSH and FT4 level, we should think about the syndrome of inappropriate secretion of TSH, including thyroid hormone resistance syndrome.