Abstract

High degree of hypertriglyceridemia is defined as the fasting blood triglyceride concentration> 11.2 mmol / L. In case high degree of hypertriglyceridemia is not promptly detected and intervened, it would be very dangerous because it not only reflects metabolic and nutritional abnormalities but also increases the risk of cardiovascular disease and acute pancreatitis... Aims: To comment on several clinical and subclinical characteristics in patients with high degree of hypertriglyceridemia at Bach Mai Hospital. Subjects and methods: Retrospective and prospective study, cross-sectional description of 88 patients with high degree of hypertriglyceridemia at Bach Mai Hospital from January 2019 to October 2020. Results: Among 88 patients, the gender ratio female/male = 1.75/1, the average age is 44.58 years old, the group of overweight and obese patients accounts for over 60%. The background diseases are diabetes mellitus (50%) hypertension (18.18%), dyslipidemia (30.68%), acute pancreatitis (29.55%) with the highest number of 5 times diagnosis for acute pancreatitis. The abuse rate for alcohol and smoking are 42.05% and 19.3% respectively. There were only 51.85% complied with dyslipidemia treatment prior to admission. The reason for hospital admission included 35.2% of patients hospitalized because of accidental detection of hypertriglyceridemia, 23.86% of patients with acute pancreatitis status due to hypertriglyceridemia. 1.1% patients with Xanthomas symptoms on the skin. The average concentration of triglyceridemia at the time of hospital admission was 26.76 ± 16.09    mmol/L. 96.6% of patients    haddisorders of cholesterol composition, 43.2% of patients had disorders LDL - C and 87.5% with HDL - C disorder. Conclusion: High degree of hypertriglyceridemia is commonly reported in male patients, people at aged 30-50 years, accompanied by overweight or obesity, history of alcohol abuse, acute pancreatitis, diabetes mellitus. The majority of patients have no symptoms of hypertriglyceridemia. The incidence of acute pancreatitis due to alcohol-related hypertriglyceridemia accounts for a high proportion, which is a heavy prognostic factor. The lifestyle that lacks of physical activities, alcohol and drinking addiction, and poor adherence to drug treatment at hospital discharge contribute to the increased risk of dyslipidemia.