Abstract

Hypovitaminosis D is associated with glucose metabolism disorders, increased insulin resistance, increased risk for type 2 diabetes and gestational diabetes, which however, has not been studied in Vietnam.Objectives: To explore relationship between plasma 25-hydroxyvitamin D level and insulin resistance pregnant women with gestaional diabetes. Subjects and methods: Pregnant women with and without gestational diabetes determined by 2-hour oral glucose tolerance  test at gestational age of 24 to 28 weeks were recruited into the study. Insulin resistance was measured by HOMA-IR in Homeostasis Assessment Model (HOMA) and vitamin D status was assessed by plasma 25- hydroxyvitamin D [25(OH)D] concentration. Results: 90 pregnant women with gestational diabetes were recruited into the study. Compared with the vitamin D sufficient group, the insufficient one had higher fasting plasma insulin level (75,00 ± 31,82 so với 7,02 ± 1,54 pmol/l, p>0,05) and significantly higher HOMA-IR (2,29 ± 1,05 so với 1,59 ± 0,79, p <0,05). Plasma   25(OH)D concentration was statistically significantly inversly correlated to HOMA-IR (r = -0,358 , p=0,001. The correlation was remained significant when being controlled by body mass index (BMI), relative weight increase and fasting plasma triglyceride level. Conclusions: Plasma 25(OH)D was associated with insulin resistance in women with gestational diabetes.