Tóm tắt

Aims: To evaluate the association between leptin and insulin, insulin resistance in prediabetic population. Patients and Methods: A total 275 prediabetic subjects were included in this study. Collected data were anthropometric characteristics and blood pressure. Fasting blood samples were obtained in early morning and assayed for serum leptin, blood glucose, HbA1c, insulin, lipid profile. Results: The concentration of serum leptin and insulin were 4,58 (2,35- 9,00) ng/mL and 8,43 (5,43-12,06)µU/mL, respectively. The prevalence of insulin resistance was 61,5%. In multivariable analysis, insulin resistance was significant associated with age, systolic blood pressure, waist circumference, cholesterol and leptin level. Leptin has a strong association with insulin resistance. Notably, this association is independent of age, gender, BMI, waist circumference and lipid profile. Conclusions: Leptin is positively correlated with insulin resistance and can predict insulin resistance in prediabetic patients.