Tóm tắt

Objectives: Type 2 Diabetes mellitus is a disease that is strongly associated with cardiovascular complications, including ischemic heart disease (IHD), the aims of this study is to determine the prevalence of HF in type 2 diabetic patients with silent ischemic heart disease (SIHD) and the risk factors of HF in those patients. Patients and Methods: A total of 51 type 2 diabetic patients who were diagnosed SIHD based on ECG and/or echocardiography and/or coronary angiogram and without chest pain, evaluated cardiovascular risk factors. Results: The prevalence of heart failure in T2DM patients with SIHD was 23.5% (12/51 patients), 10/12 patients had systolic heart failure and 6/12 patients with heart failure had combinations of both LV diastolic and systolic dysfunction. LV diastolic and systolic dysfunction had rigorously significant relation with heart
failure. Previous MI was the major cause of LV systolic dysfunction and LV wall motion abnormalities. Male and smoking may be seen as the risk factors of MI in T2DM patients with SIHD. Conventional lipid parameters, lipoprotein ratios were not predictor of MI in T2DM patients with SIHD. However, not all patients with previous MI develop LV systolic dysfunction. So a role of timely diagnosis, early percutaneous coronary intervention are the most important for the patients with acute MI. Left ventricular diastolic dysfunction, an early sign of diabetic cardiomyopathy, and cardiac autonomic neuropathy contributed to higher prevalence and severer of congestive HF in T2DM patients with SIHD.