Cardio-metabolic risk factors in Vietnamese men on vegetarian diet.

Ngôn ngữ sử dụng

Cách trích dẫn

Thuy, N. H., Chi, L. V., Anh, N. T. K., Tram, N. H. Q., & Minh, N. H. N. . (2021). Cardio-metabolic risk factors in Vietnamese men on vegetarian diet. Vietnam Journal of Diabetes and Endocrinology, (30), 46-58. Truy vấn từ https://vjde.vn/journal/article/view/166

Tóm tắt

Background: Numerous cross-sectional studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, whether long-term vegetarian diet might be cardiometabolic risk factors are still unclear.
Objectives: To investigate the influence of vegetarian diet on cardiometabolic risk factors, and more importantly on plasma levels of testosterone and leptin among vegetarian males
in Vietnam. Methods: 93 Vietnamese males (age 16-78 years) with duration of vegetarian diet ranged 5-65 years, were screened for cardiometabolic risk factors including BMI, WC, blood pressure, fasting glucose, HbA1c, fasting insulin, HOMA-IR, HOMA-%B, lipid profile, serum levels of hsCRP, Leptin and Testosterone, and the control group was 86 non-vegetarian men (age 17-72 years).
Results: The vegetarian group had lower prevalence of metabolic syndrome compared to the non-vegetarian one (12.9% vs 24.4%, p <0.01), lower serum hsCRP concentration (0.85 ±0.94 vs 4.21 ±5.73 mg/l, p < 0.05), lower serum total cholestrol (4.05 ± 0.92 vs 5.21 ± 1.21 mmol/l, p<0,01), lower LDL.C (2.07 ± 0.72 vs 3.39 ± 1.09 mmol/l, p<0.01), lower non-HDL.C (2.88 ± 0.96 vs 4.04 ±118 mmol/l, p<0.01), lower TC/HDL.C ratio (3.62 ± 1.18 vs 4.67 ± 1.33, p<0.01), and lowerLDL.C/HDL.C ratio (1.86 ± 0.81 vs 3.06 ± 1.15, p<0.05), respectively. In contrast, serum Testosterone level was higher in vegetarian males (6.37 ±1.78 vs 5.29 ± 2.38 ng/ml, p=0.008). Between the vegetarian and nonvegetarian men, there were no differences in BMI (22.13 ± 3.59 vs 22.56 ± 2.88, p>0.05 ),in WC (77.61 ±8.62 vs 79.76± 7.14 cm, p>0.05), in SBP (116.88±12.20 vs 122.31±13.77 mmHg, p>0.05),in DBP (77.84 ±8.77 vs 77.76±10.00 mmHg, p >0.05), in fasting glucose ( 4.65 ± 0.53 vs 5.05 ± 0.68 mmol/l , p > 0.05), in fasting insulin (5.85 ± 4.53 vs 5.93 ± 3.2 µU/ml, p>0.05),in HOMA-IR (1.25 ±1.18 vs 1.3 ±0,83, p>0.05), in TG (1.81 ± 1.04 vs 2.03 ± 1.16 mmol/l, p >0.05), in HDL.C (1.17 ± 0.25 vs 1.17 ± 0.31 mmol/l , p >0,05), and in TG/HDL.C (1.71 ± 1.26 vs 1.88 ± 1.25, p >0.05), respectively. Compared to non-vegetarian group, the vegetarian one had lower serum concentration of leptin (1.46± 1.48 vs 3.16 2.95 ng/ml, p < 0.01),higher serum testosterone level ( 6.37 ±1.78 vs 5.29 ± 2.38, p=0.008) but higher HbA1c level (5.51± 0.71 vs 4.96 ±0.69%, p < 0.01) and higher prevalence of prediabetes based on HbA1c ≥ 5.7 % (35,5% vs 5.8%, p < 0.01), respectively. There was a correlation between HbA1c level with age, duration of vegetarian diet, BMI, WC, TG, leptin and testosterone levels; in which the vegetarian duration was identified as an independent risk factor of hyperglycemia by multiple regression analysis. The vegetarian duration cut-off point for prediabetes analyzed by ROC was 21 years and the age cut-off point for prediabetes was 35 years old, which was younger than in non vegetarians (46 years old).
Conclusions: A decrease in multiple cardiometabolic risk factors such as BMI, blood pressure and lipid profile was associated with vegetarian diet. However, long-term vegetarian diet could cause hyperglycemia and hypoleptinemia. Those effects appeared to be correlated with the vegetarian duration (more than 21 years).