Abstract

Background: Hypothyroidism is a common thyroid disease, which can affect much to quality of life. Clinical menifestations are not specific but hypothyroidism is readily diagnosed and managed by laboratory features. Objectives: Describe clinical and laboratory features of hypothyroidism. Methods: This cross-sectional study is carried out in 201 patients included 79 patients who have been diagnosed as hypothyrodism for the first time and 122 patients who was diagnosed as hypothyroidism and have been treated with stable Levothyroxine dose in at least 6 weeks, managed at Hanoi Medical University hospital from Novemver 2019 to August 2020. Results: In the vast majority of cases, hypothyroidism is caused by thyroid diseases (primary hypothyroidism). Fatigue is the most common clinical manifestation, which presents in 53,2% patients newly diagnosised of hypothyrothysm. Other common symptoms are dry skin, cold intolerance, weight gain (approcimated 25%). The prevalence of dyslipidemia is 88,6% in newly diagnosised group and 86,9% in treated group, hypertriglyceridemia is the most common with 69,6% and 68,9%, respectively. The average replacement doses of Levothyroxine in adults is 1,39 mg/kg body weight per day, but the range of required doses is wide. Conclusions: Because of the lack of specificity of the typical clinical manifestations, the diagnosis of hypothyroidism is based primarily upon laboratory testing. The main causes of hypothyroidism are thyroid diseases (primary hypothyroidism). The replacement doses of Levothyroxine is variable.