Abstract

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an independent risk factor for atherosclerosis. Recently, the increasing evidence has showed that hypertriglyceridemia (HTG) is associated with incremental ASCVD risk. Hypertriglyceridemia is a very common problem in clinical practice with a prevalence of approximately 10%. High triglyceride concentration are markers for several type of TG rich lipoproteins (TRL) such as VLDL, IDL, especially LDLsdand apolipoproteinsC-III. Patients with HTG may be at significant risk for ASCVD even if LDL cholesterol levels are at goal with Statins, and therefore warrant treatment that promotes regular exercise, optimizes diet and reduces overweight.... HTG in patients with type 2 Diabetes Mellitus, ASCVD, or metabolic syndrome… may benefit from additional drug including Fibtrates, Omega-3 polyunsaturated fatty acids (PUFAs) treatment aside from a Statins to address other lipid abnormalities.