Background: Thyroid cancer accounts for 1% of all cancers. This is the most common type of malignant tumor affecting the endocrine system. The disease usually progresses slowly, mainly develops locally and metastases of neck lymph nodes. If detected early, it is possible to select appropriate treatment methods which will result in high efficiency. Objectives: Analyzing the clinical and subclinical characteristics of selected differentiated thyroid cancer patients in laparoscopic surgery. Methods: 115 thyroid cancer patients were performed endoscopic thyroidectomy at National Hospital of Endocrinology from March 2012 to April 2018. Results: 115 thyroid cancer patients were undergone endoscopic thyroidectomy at National Hospital of Endocrinology included 109 females (94.8%) and 6 males (5.2%). The proportion of female/male is 18/1. Age of patient is 15 to 45. Mean age of male was 30.4 ± 6.4 and 33.2 ± 4.5 of female. The mean age for the whole world is 32.7 ± 6.8. Mainly disease ages 25 - 35 (74.8%). 68.7% of patients were treated by surgery 12 months after diagnosis and after 36 months of diagnosis: 13.9%. The mean time from detected until done by surgery was 10.3 ± 6.7 months. 100% of patients with thyroid nodule. 80% of patients with solid density. The most of nodules were not clear boundaries (92.2%). 21.7% surface roughness, 80% nodules with solid density. 60/115 (52.18%) with metastatic neck lymph nodes, of which 61.7% central cavity lymph nodes; 38.3% bilateral metastatic neck lymph nodes. Papillary cancer accounted for 76.5%; 10.4% follicular, 13.1% papillary-follicular. Compare the results of FNA with pathology: 78.9% positive and false-negative rate was 7.8%.