Abstract

Background: Hyperuricemia can lead to gout and is associated with a number of metabolic syndromes, cardiovascular disease, diabetes, and kidney disease. Several recent studies have demonstrated that increased uric acid is a risk factor for hypertension, dyslipidemia, cardiovascular disease, and kidney disease. However, the correlation between uric acid and type 2 diabetes remains controversial. Objectives: To evaluate serum uric acid levels in patients of Type 2 Diabetes Mellitus and to correlate serum uric acid levels with glycemic parameters in patients of Type 2 Diabetes Mellitus. Method: Retrospective study. Blood glucose, HbA1C and uric acid data were collected at the Laboratory Department of Tien Giang General Hospital. Results: 53 patients and 53 controls were included. Fasting blood sugar (FBS), HbA1cand acid uric were measured. Based on FBS levels classification, the results showed that uric acid levels of patient group II and III were higher than group I and this difference was statisticallysignificant (p<0.01). No statistically significant difference between group II and group III (p > 0.05). In contrast, the uric acid level of patients in group IV was lower than in groups I, II, and III, the difference was statistically significant (p < 0.001). Based on HbA1c levels classification, the results showed that the uric acid level increased in the group of patients with HbA1C from 6.0 to 9.9%, whereas the uric acid concentration decreased in the group of patients with HbA1C > 10%. Conclusion: We found increase in serum uric acid in cases compared to controls. Serum uric acid initially increased with increase in FBS and HbA1c ranging from 7.0 – 15.3 mmol/L and 6.0 – 9.9 % respectively and thereafter decreased with further increase in FBS and HbA1C