Abstract

Background: The metabolic syndrome is a constellation of cardiometabolic risk factors that tend to cluster together in affected individuals more often than predicted by chance. The presence of the metabolic syndrome substantially increases the risk of developing type 2 diabetes and cardiovascular disease, and is associated with a range of adverse clinical outcomes, many of which are closely associated with aging. Recent studies show that low vitamin D status is very common in the world and this is a risk factor of metabolic syndrome. Objective: (1). Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome. (2). Relationship between plasma 25-hydroxyvitamin D concentration and risk factors for metabolic syndrome. Material and method: A cross-sectional study with control group on 275 adult subjects for health examinations at International Medical Center at Hue Central Hospital, including 94 subjects with metabolic syndrome and control group of 181 healthy subjects. Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Plasma hydroxyvitamin D concentration was measured using chemiluminescent microparticle immunoassay. Results: Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome was 27,8 ng/mL, incidence of plasma 25-hydroxyvitamin D deficiency (87,2%) was significantly higher than in control group (24,9%) (p<0,001). The plasma 25-hydroxyvitamin D concentration was inverse correlation with waist circumference, BMI, total cholesterol, triglycerid, reduce HDL-C, systolic blood pressure, diastolic blood pressure and HbA1C (p <0,05 to p <0,001). Conclusion: The plasma 25-hydroxyvitamin D concentration at subjects with metabolic syndrome was 27,8 ng/mL and the incidence of 25-hydroxyvitamin D deficiency in the metabolic syndrome group was 87,2%. The plasma 25-hydroxyvitamin D concentration was inverse correlation with waist circumference, BMI, total cholesterol, triglycerid, reduce HDL-C, systolic blood pressure, diastolic blood pressure and HbA1C.