Abstract
Objective: To evaluate the relations and correlation between glutamic acid decarboxylase antibody (GADA) condition and some of paraclinical characteristics in non overweight - obesity diabetic patients. Subjects and method: A cross-sectional study on 284 non overweight- obesity diabetic patients at Hue Central Hospital from August, 2017 to June, 2019. A total of 284 samples were taken to assess the lipid profile, HbA1C, glucose and insulin concentration in non- overweight, obese diabetic individuals. Venous blood samples were taken from all the subjects in the morning after fasting overnight. All patients were measured autoantibodies glutamic acid decarboxylase (anti-GAD). GAD antibody- positive was determined when autoantibodies to GAD concentration was higher than 5 IU/mL. The data was analyzed using Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA). Results: Concentration of glucose and HbA1C in GAD antibody- positive group were higher than in GAD antibody- negative group (15.98±12.64 mmol/l vs 11.66±8.39 mmol/l); (8.9±2.25% vs 8.83±2.6%), respectively. In GAD antibody- positive group, hypoinsulinemia accounted for 4.55%; hyperinsulinemia accounted for 13.63%; and normal insulinemia accounted for 81.82%. In non-overweight, obese diabetic individuals, the percentage of dyslipidemia was 73.59%; in which, this percentage of GAD antibody- positive group was 73.28% and of GAD antibody- negative group was 77.27%. In GAD antibody- positive group, the percentage of hypertriglyceride, decreased HDL-cholesterol and increased LDL-cholesterol were lower than in negative group. Conclusion: There was a slight positive relation between glucose concentration and GADA.
