Abstract
Background: Nephrotic syndrome is characterized by prolonged and excessive urinary excretion of protein and has led to a decrease in serum albumin and several other plasma proteins such as iron, transferrin (TRF), and serum ferritin. Iron, TRF, and serum ferritin disorders may contribute to deteriorating renal disease and a poorer prognosis in nephrotic syndrome patients. This study aims to examine the association betweeniron, TRF, and ferritin levels and serum albumin in patients with nephrotic syndrome. Subjects and methods: This study is a descriptivecross-sectional included 68 patients in adults with primary nephrotic syndrome without renal failure. Results: The average serum iron concentration is 6.9 mol/L, and low-level accounts for 30.9%; in all patients, serum TRF concentration was below normal, averaging 0.68 mmol/L; The average serum ferritin concentration was 610.3 pmol/L and at high level accounted for 67.6%. Serum iron and TRF concentrations were positively correlated with serum albumin, whereas serum ferritin concentrations were negatively correlated with albumin levels (p<0.05). Conclusion: Albumin concentration was positively correlated with serum iron and TRF, but negatively correlated with serum ferritin concentration