Abstract
Objective: To determine the correlation between serum vitamin D and some factors related to chronic kidney damage in diabetic nephropathy (DN) patients Method: We randomly selected 120 type 2 diabetic patients with non replacement renal disease, with eGFR < 60ml/p and ACR > 30mg/g. Study subjects were quantified for 25(OH) D, HbA1c, as well as variables related to chronic kidney damage such as ACR, eGFR, PTH and hemoglobin levels. We determined the correlation between serum vitamin D and these variables, and analyzed the logistic regression between vitamin D deficiency and factors related to chronic kidney damage in the study population. Results: There was a positive correlation between 25(OH) and eGFR, hemoglobin with correlation coefficients of r=0.23; 0,4 (P<0.01), respectively. There was a negative correlation between 25(OH)D and PTH, ACR with equal correlation coefficients of r=- 0.3 (P<0.05). Multivariate logistic regression analysis showed a significant correlation between 25(OH)D deficiency and severe urinary albumin excretion (ACR≥ 300mg/g) with an OR of 5.1 (CI95%, 1.1-7.2) P<0.05 Conclusion: There is an independent correlation between vitamin D deficiency and macroalbuminuria. The more severe the progression of kidney damage, the more severe the vitamin D deficiency.